Neuroendocrine tumors

Neuroendocrine tumors (NETs) (historically called APUDomas) represent a wide spectrum of disease. They consist of a large heterogeneous group of malignancies that are derived from embryonic neural crest tissue found in various organ such as the hypothalamus, pituitary gland, thyroid gland, adrenal medulla, and gastrointestinal tract. 

The spectrum of neuroendocrine tumors range from:


They can also be divided by their biochemical behavior as functioning or non-functioning, by their aggressiveness as slow-growing and more aggressive lesions and so on.

Because of secretory products by amine precursor uptake and decarboxylation (APUD) they were historically known as APUDomas.


Mostly occur sporadically, some are linked to multiple endocrine neoplasia syndromes.

Article information

rID: 28523
System: Oncology
Tag: net
Synonyms or Alternate Spellings:
  • Neuroendocrine tumour
  • Neuroendocrine tumor
  • Neuroendocrine tumors
  • NET
  • APUD
  • Neuroendocrine tumours (NET's)
  • Neuroendocrine tumour (NET)
  • APUDomas

ADVERTISEMENT: Supporters see fewer/no ads

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.