Multiple myeloma

Case contributed by Dr Mohammad Osama Yonso

Bony lytic lesions in skull are well defined, as if 'punched out'.

Case Discussion

Multiple myeloma is the most common primary malignant bone neoplasm in adults and results in a wide range of radiographic abnormalities.

Multiple myeloma may simulate carcinomatosis radiologically, but is distinguishable from it by the absence of a known primary lesion and the presence of Bence-Jones proteins in the urine, an abnormal serum electrophoretic pattern with an excess of gamma globulin, and myeloma cells in a marrow biopsy sample.

Four main radiological patterns are recognized 9:

  • type 1: solitary - similar in appearance to bone cysts
  • type 2: multiple osteolytic lesions without marginal sclerosis
    • central
    • peripheral
  • type 3: diffuse osteoporosis with generalized involvement
  • type 4: diffuse osteosclerosis
PlayAdd to Share

Case information

rID: 17706
Published: 6th May 2012
Last edited: 13th Aug 2019
Tag: skull
Inclusion in quiz mode: Included

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.